ncRNA name | hsa-miR-200b |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | human retinal microvascular endothelial cell (HRMECs) |
Methods | RT-PCR, Western blot, CHIP-qPCR, ELISA, siRNA transfection |
Expression pattern | down-regulated |
Functional description | Human retinal microvascular endothelial cells exposed to high levels of glucose regulate miR-200b repression through histone methylation and that inhibition of PRC2 increases miR-200b while reducing VEGF. |
PubMed ID | 25884496 |
Year | 2015 |
Title | Polycomb repressive complex 2 regulates MiR-200b in retinal endothelial cells: potential relevance in diabetic retinopathy. |
Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.